New Protein Discovered That Mimics Exercise Benefits and Protects Bones Without Movement
Researchers from the University of Hong Kong have made a significant scientific discovery that could transform the prevention and treatment of osteoporosis by identifying a new protein known as Piezo1.
This protein functions as an "internal movement sensor" within bones, allowing them to reap the benefits of physical activity even when no actual movement occurs.
* The Protein That Mimics Exercise Within the Body
A study published in the journal Signal Transduction and Targeted Therapy revealed that Piezo1 acts as a mechanical sensor, detecting movement and pressure signals in stem cells located in the bone marrow.
When activated by movement, this protein encourages stem cells to generate bone tissue rather than fat, thereby lowering the risk of bone mass loss.
Conversely, a deficiency of this protein leads to fat accumulation in the bones and increased inflammatory signals, which can further compromise bone health.
* Medications That Mimic Exercise for Patients Unable to Move
Professor Shou Aimin, the lead researcher and head of the biological pharmaceutical technology lab at the University of Hong Kong, noted that this discovery opens new avenues for developing medications that could enable the body to "mimic" the effects of exercise at the cellular level, particularly for older adults or patients unable to exercise due to chronic illnesses or prolonged bed rest.
* Addressing Osteoporosis: A Health Issue Affecting Millions
Osteoporosis is a major health concern for the elderly worldwide; according to the World Health Organization, one in three women and one in five men over the age of 50 suffer fractures due to weakened bones.
Bone health declines with age as bone density decreases and porosity increases, making bones more susceptible to fractures.
* A Step Towards the Future: Pharmacological Exercise Imitation
By identifying this protein, scientists have a clear target for developing new treatments that can effectively replicate the benefits of exercise.
These medications could help reduce fracture risk and enhance the quality of life for patients, especially in light of the growing aging population in many countries.
The research team is currently working to advance these findings into clinical trials, aiming to create medications that maintain bone strength and minimize bone mass loss, representing a scientific breakthrough that could significantly change the approach to bone health and osteoporosis prevention.
